ACTA1 and triple-A syndrome: Prevention of AAA formation by CsA was accompanied by an increased density of αSMA-positive cells in the neointima in elastase-perfused aortas (Figure 3A) and by a higher number of αSMA-positive cells in the media in mice (αSMA-positive cells per mm2: 2856±765 vs 1697±732 in CsA- and vehicle-treated mice, respectively, P = .047) (Figure 3B).