Therefore, we examined the mRNA level of SRD5A3 in different xenograft models, including MDA PCa 183, an AR-expressing androgen-dependent prostate cancer xenograft, and three AR-negative androgen-independent SCPC xenografts, MDA PCa 144, MDA PCa 146, and MDA PCa 155. The gene discussed is SRD5A3; the disease is prostate cancer.