ANG and osteosarcoma: Angiogenin (ANG) is up-regulated in various types of human cancer, including breast, cervical, colon, colorectal, endometrial, gastric, liver, kidney, ovarian, pancreatic, prostate, and urothelial cancers, as well as astrocytoma, leukemia, lymphoma, melanoma, osteosarcoma, and Wilms' tumor [1], indicating a close relationship between ANG and tumor development.