An allelic association between CRHR1 rs242939 and recurrent MDD was found in our sample (allelic: p = 0.018, genotypic: p = 0.022) with an Odds Ratio of 0.454 (95% CI 0.266–0.775), which is reflected by a significant increase of the G-allele of 242939 in the recurrent MDD group than the control group. This evidence concerns the gene CRHR1 and major depressive disorder.