An increasing number of IFN-signaling-deficient lung cancer cells (from ∼30% to ∼70%) were killed by raising dose of VSV exposure and adding IFNα to the medium failed to inhibit cytotoxicity of high dose VSV (MOI5) in CRL5800, CRL5810 and CRL5869 cells (Figure 1A). Here, IFNA1 is linked to lung carcinoma.