Because functional inactivation of IFN pathway has been a common trait of many cancers, we used 7 long-term lung cancer cell lines (4 adenocarcinomas: CRL5800, CRL5807, CRL5810 and CRL5872, 2 squamous carcinomas: HTB172 and CRL5928 and 1 small cell carcinoma: CRL5869) to study the changes in their innate immune system. The gene discussed is IFNA1; the disease is lung cancer.