A strong polyI:C-induction of phosphorylated-STAT1 (p-STAT1, Ser727), STAT1, IRF5 and IRF7 protein levels was consistent with the resistance of normal Beas2B cells and the two cancer cells, HTB182 and CRL5928, to VSV infection and vice versa for the viral-sensitive lung cancer cell line. The gene discussed is STAT1; the disease is lung cancer.