Individual restoration of IRF expression partially protected CRL5810 cells from VSV cytolysis with the greatest increase of cell viability from ∼50% to more than 85% at MOI0.05, and from ∼30% to ∼50% at MOI5 of VSV infection in cells overexpressing both IRF5 and IRF7 compared to vector control cells (Figure 4B). This evidence concerns the gene TRIM63 and infection.