Neither of these two IRF transcription factors was able to be induced in VSV-sensitive lung cancer cells (Table 2 and Figure 1B), whereas overexpression of IRF5 and/or IRF7 in immortal LFS fibroblasts upregulated other ISGs, manifested a faster and stronger innate immune signaling upon dsRNA stimulation, which is sufficient to induce senescence [15]. This evidence concerns the gene IRF5 and lung cancer.