SLC22A12 and gout: Vázquez-Mellado et al. reported patients heterozygous for C850G in URAT1 with primary gout and low serum uric acid concentrations [50] whilst Ichida, et al. reported 5 individuals with a W258X heterozygous change, one of whom had a history of acute kidney injury and renal stones [23], [31], [36].