The ability of PEG-TNYL-RAW to disrupt the coordinated interplay of endothelial and perivascular mesenchymal cells suggests that this peptide could be used to: (1) enhance the effectiveness of anti-angiogenic cancer treatments targeting vascular endothelial growth factor (VEGF) or VEGF receptor, which preferentially affect smaller blood vessels lacking a perivascular cell component and (2) disrupt the remodeled blood vessels of tumors that have recurred after anti-VEGF treatments, which are typically stabilized by perivascular mesenchymal cells [63], [64], [65], [66]. This evidence concerns the gene VEGFA and cancer.