TROP2, also known as EGP-1, M1S1, GA733-1, and TACSTD2, is a 36-kDa membrane glycoprotein, initially identified as a tumor-associated calcium signal transducer (TACSTD) expressed in gastrointestinal, bladder, lung, and cervix carcinomas and later found to be highly expressed in many other tumors including pancreatic cancers and squamous cell carcinomas of the oral cavity [1]. Here, TACSTD2 is linked to oral cavity squamous cell carcinoma.