TROP2, also known as EGP-1, M1S1, GA733-1, and TACSTD2, is a 36-kDa membrane glycoprotein, initially identified as a tumor-associated calcium signal transducer (TACSTD) expressed in gastrointestinal, bladder, lung, and cervix carcinomas and later found to be highly expressed in many other tumors including pancreatic cancers and squamous cell carcinomas of the oral cavity [1]. The gene discussed is TACSTD2; the disease is familial pancreatic carcinoma.