The increased frequency of EZH2 mutations was statistically significant in the FL group (28% of BCL2-R cases versus 0% of BCL2-WT cases, p<0.05), the DLBCL group (33% of BCL-R cases versus 4% of BCL2-WT cases, p<0.04), and across all lymphoma types excluding BL, which universally lacked both BCL2 rearrangements and EZH2 mutations (27% of BCL2-R cases versus 3% of BCL2-WT cases, p<0.003) (Figure 2). Here, EZH2 is linked to lymphoma.