[1], [2] As new discoveries have improved our understanding of the genetics and phenotypic characteristics of B cell lymphomas, it has become clear that some oncogenic mutations occur with increased frequency, or even exclusively, in lymphomas of a certain phenotype. One prominent example is the t(14;18)(q32;q21) IGH-BCL2 rearrangement, which leads to overexpression of the Bcl-2 oncoprotein, and is frequently present in follicular lymphoma and GCB-DLBCL, but not in other gene expression-defined subtypes of DLBCL. [3]. The gene discussed is BCL2; the disease is lymphoma.