[13] Our results are consistent with those of a recent study which used deep-sequencing techniques (genome, exome, and RNA sequencing) on a small number of follicular lymphomas and reported EZH2 mutations in 4/13 cases (31%). [14] Thus, the true rate of EZH2 mutations in follicular lymphoma may be higher than originally reported. EZH2 mutations were not enriched in more proliferative subgroups of FL (low grade/high PI FL and grade 3 FL), suggesting that EZH2 mutations are not associated with known aggressive subtypes of FL. This evidence concerns the gene EZH2 and follicular lymphoma.