Of the 7 independent clones we sequenced, all contained the exon 8–9 splice junction seen in EZH2 Refseq isoform C (NM_001203247), corresponding to the Y641 codon designation used in the initial description of the lymphoma mutation, [4] while no clones contained the exon 8–9 splice junction seen in the slightly longer EZH2 Refseq isoform A (NM_004456), which has been used as a reference transcript in some later work, resulting in designation of the same residue as Y646. This evidence concerns the gene EZH2 and lymphoma.