There was no significant correlation between PDCD4 expression (nuclear or cytoplasmic) and mir-21 expression in these samples, however we observed a general grouping of ICC with high mir-21 but not PDCD4, and CIN-2,3/CIS with higher PDCD4 but non-elevated mir-21 (Figure 4). The gene discussed is PDCD4; the disease is in situ carcinoma.