BDNF and Alzheimer disease: Figure 9C shows that J147 restores the expression of this protein relative to untreated huAPP/PS1 mice. The phosphorylation of the scaffold protein PSD95 is mediated by BDNF [50]. Figure 9D shows that J147 greatly increases the phosphorylation of PSD95 at Tyr 236 and 240 in huAPP/PS1 mice relative to both control and untreated AD mice. J147 does not, however, require the expression of the BDNF receptor TrkB for its neuroprotective activity (Fig. 2B) and the levels of TrkB in the AD mice are not altered by J147 (not shown).