Furthermore, a recent report by Reddi et al. [31] demonstrated that forced expression of the PAX8-PPARγ fusion protein, a putative dominant-negative form of PPARγ, in a DTC-derived thyroid cancer cell line (WRO), caused a striking 5-fold reduction in tumor progression in a mouse xenograft model. The gene discussed is PAX8; the disease is thyroid gland carcinoma.