Similarly, GSEA of hsa-miR-519a-transfected STF-3a cells showed significant enrichment of the geneset LIN_WNT_UP, comprising Wnt target genes identified by expression of the Wnt antagonist APC in APC-deficient SW480 colon cancer cells [28] (bottom panel, Figure 3C). This evidence concerns the gene APC and malignant colon neoplasm.