In contrast to the transcriptional regulation of ftn-1 and ftn-2 in C. elegans, vertebrate ferritin H- and -L subunit mRNAs are translationally repressed during iron deficiency by the binding of IRP1 and IRP2 to an iron-responsive element (IRE) in ferritin mRNAs [26]. The gene discussed is ACO1; the disease is nutritional disorder.