PIM3 and Familial prostate cancer: We have recently characterized a novel small molecule designated M-110, as a highly selective inhibitor of all three PIM kinase isoforms and showed that M-110 inhibits, through inhibition of PIM-3, but not of PIM-1 or of PIM-2, the phosphorylation of STAT3 on tyrosine residue 705 in the prostate cancer derived cell line DU-145 and the pancreatic cancer derived cell line MiaPaCa2 [16].