PIM-1 and PIM-2 are implicated in prostate cancer development [2, 3], PIM-1 is over expressed in head and neck squamous cell carcinoma and bladder cancer [4, 5] and PIM-3 is over expressed in colorectal, pancreatic and hepatocellular carcinoma [6-8]. This evidence concerns the gene PIM1 and head and neck squamous cell carcinoma.