HSV-1 infection is implicated in Alzheimer's disease susceptibility by virus binding to HSPGs, nectin receptors, α2-macrolgobulin, blood-borne lipoproteins, and apolipoprotein E. Cholesterol reduction on the plasma membrane by a cholesterol synthesis inhibitor has been linked to a decrease in the risk for development of Alzheimer's dementia. Here, APOE is linked to Alzheimer disease.