Reduced HHV-8 infection and decreased cellular signals associated with the virus infection by raft disruption suggest that membrane rafts in microvascular dermal endothelial cells are required for HHV-8 infection and gene expression, due to their potential roles in the modulation of HHV-8-induced PI3K, RhoA-GTPase, and Diaphanous-2 (a RhoA-GTPase-activated adaptor molecule involved in microtubule activation) signal molecules, which play roles in virus entry processes after receptor binding [30]. This evidence concerns the gene RHOA and viral infectious disease.