For example melanoma secretes oncostatin M (OSM), which transmits its signal via the gp130 cell surface receptor, resulting in the selective downmodulation of the melanocyte lineage antigens: Melan-A/MART-1, gp100, tyrosinase, tyrosinase-related proteins 1 and 2, and the M isoform of microphthalmia transcription factor [71]. This evidence concerns the gene PMEL and melanoma.