Consequently, when liver MNCs obtained from surgical liver specimens of cirrhosis patients with HCC were cultured with IL-2, IL-12, and IL-15, they showed decreased IFN-γ production and antitumor cytotoxicity against both K562 cells and Raji cells, which was also the case against an HCC cell line (HuH-7 cells) [52]. This evidence concerns the gene IFNG and hepatocellular carcinoma.