The molecular hallmark of BL is a chromosomal rearrangement of MYC, in form of reciprocal translocation, juxtaposing MYC to the immunoglobulin heavy chain (IGH locus [(t(8; 14)(q24; q32)]) or the κ or λ light chain loci (t(2; 8)(p12; q24) and t(8; 22)(q24; q11), resp). The gene discussed is MYC; the disease is Burkitt lymphoma.