BCL2 and diffuse large B-cell lymphoma: The first subgroup of DLBCL, called germinal center B-cell-like (GCB) DLBCL, expresses genes that are characteristic of normal germinal center B cells and is characterized by frequent REL amplifications, BCL2 translocations, and ongoing somatic hypermutation of the immunoglobulin genes [30, 34, 35].