Mixed-Lineage-Leukemia (MLL) gene is one of the most frequently involved genes in hematologic malignancies, in particular in some forms of acute leukemia, both lymphoblastic and myeloid; the Atlas of Genetics Oncology (http://atlasgeneticsoncology.org/Anomalies/11q23ID1030.html) reports 73 recurrent translocations and 54 chromosome loci as partner site of reciprocal translocations involving the band 23 of the long arm of chromosome 11 (11q23), in particular MLL gene. Here, KMT2A is linked to acute leukemia.