UPR signalling has been shown to be required for sustained autophagy under hypoxia in colorectal carcinoma and glioma cells which were not able to maintain the LC3 levels required for autophagy under prolonged hypoxia when the ATF4-activating protein, PKR-Like ER Kinase (PERK) (Figure 1), was disrupted [29]. The gene discussed is EIF2AK3; the disease is colorectal carcinoma.