ZEB1 and posterior cortical atrophy: The demonstration that tcf8 is regulated by androgen, the high expression of ZEB1 mRNA in aggressive PCa cell lines, ZEB1's role in PCa cell migration [26, 31], ZEB1's correlation with Gleason grade in human PCa samples [26], and the increased expression of ZEB1 in primary PCa and associated bone metastases [39] raises the possibility that aberrant expression of tcf8 might promote PCa metastasis.