On the contrary, the profile of [Pten, p53]thyr−/− ATCs (8-10 months of age) was strikingly different from that of younger [Pten, p53]thyr−/− mice and also from that of well-differentiated follicular carcinomas developed by aging Ptenthyr−/− mice (16-20 months). Here, PTEN is linked to thyroid gland follicular carcinoma.