Our previous study indicated that CYP2J3 overexpression significantly reduced insulin resistance, decreased blood pressure and prevented eNOS downregulation induced by fructose intake[9], and possibly CYP2J3 gene delivery reduced blood pressure through upregulated eNOS expression and downregulated endothelin-1 (ET-1) and endothelin receptor A (ETA) expression. Here, EDN1 is linked to Insulin resistance.