This process is primarily coordinated by the disappearance or loss of epithelial biomarkers such as E-cadherin with the concomitant appearance or gain of mesenchymal markers such as vimentin, fibronectin and N-cadherin, etc. In the present study, GSPs treatment of SCC13 cells showed the suppression of mesenchymal biomarkers, such as vimentin, fibronectin and N-cadherin while restored the levels of epithelial biomarker such as, E-cadherin, in human cutaneous head and neck SCC cells which suggest that GSPs have the ability to reverse the EMT process in HNSCC cells. Here, CDH2 is linked to head and neck squamous cell carcinoma.