This process is primarily coordinated by the disappearance or loss of epithelial biomarkers such as E-cadherin with the concomitant appearance or gain of mesenchymal markers such as vimentin, fibronectin and N-cadherin, etc. In the present study, GSPs treatment of SCC13 cells showed the suppression of mesenchymal biomarkers, such as vimentin, fibronectin and N-cadherin while restored the levels of epithelial biomarker such as, E-cadherin, in human cutaneous head and neck SCC cells which suggest that GSPs have the ability to reverse the EMT process in HNSCC cells. The gene discussed is VIM; the disease is head and neck squamous cell carcinoma.