These biomarkers, such as CK19, TG, Ki67, Calcitonin, TTF-1, BRAF, RET, HBME-1, and galectin-3, have been translated into clinical practice which offered significant improvement in the preoperative diagnosis of thyroid cancer [3-6,8,11,12]. The gene discussed is TTF1; the disease is thyroid gland carcinoma.