TAFs are contractile cells, associated with blood vessels, and able to produce growth factors (HGF, TGF-β, EGF, bFGF, and IGF), cytokines, chemokines, and enzymes, to degrade the extracellular matrix, and to act as immunomodulating cells, thus increasing tumor growth by creating a microenvironment suitable for this process [12, 17, 18]. The gene discussed is IGF1; the disease is neoplasm.