Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, along with Irf4 transcription factor, was determined to be essential for macrophage colony-stimulating factor (M-CSF)-bone-marrow-derived M2 macrophage polarization in response to Nippostrongylus brasiliensis helminth infection and chitin inoculation [59]. The gene discussed is KDM6B; the disease is helminthiasis.