For example, disruption of EZH2 by DZNep or by short-hairpin RNAs (shRNAs) was shown to significantly impair self-renewal and the tumour-initiating capacity of glioblastoma cancer stem cells (Suva et al, 2009) or ovarian cancer stem cell-like populations (Rizzo et al, 2011). The gene discussed is EZH2; the disease is neoplasm.