EZH2 expression can also be transcriptionally activated by a fusion oncoprotein EWS-FLI1 in Ewing's sarcoma, and induced EZH2 expression has a key role in endothelial/neuroectodermal differentiation and tumour growth (Richter et al, 2009; Table 1). Here, EZH2 is linked to Ewing sarcoma.