Several reports suggest that EZH2 directly interacts with DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) and that EZH2 is necessary for the maintenance of DNA methylation and stable repression of specific genes, including many tumour suppressors (Sauvageau and Sauvageau, 2010). The gene discussed is EZH2; the disease is neoplasm.