AGT and neoplasm: Concern regarding the potential role of Ang II in angiogenesis and promotion of tumour growth has been growing in the past few decades (Egami et al, 2003; Juillerat-Jeanneret et al, 2004; Ager et al, 2008; George et al, 2010), and Lever et al reported the first clinical evidence that long-term Ang II blockade might have a protective effect against carcinogenesis (Lever et al, 1998).