As chaetocin serves as a potent inducer of cellular ROS, apparently consequent to its ability to inhibit thioredoxin reductase-mediated ROS remediation, we postulated that chaetocin might not only have activity in myeloma, but also in solid tumours, as the imposition of cellular ROS has been postulated to represent an attractive candidate therapeutic strategy in solid tumours (Fang et al, 2007). The gene discussed is PRDX5; the disease is plasma cell myeloma.