HIF1A and neoplasm: In parallel, we also examined HIF-1α protein levels in treated vs control tumour lysates and additionally in treated vs control SKOV3 cells in vitro; in each instance HIF-1α was barely detectable, providing no indication that HIF-1α was required for the antitumour effects of chaetocin in vitro or in vivo in the utilised SKOV3 model systems.