ANXA2 and neoplasm: Colon 1 showed significantly elevated oxidation of total proteins in the outer and core tumors consistent with the high level of ANXA2 oxidation in these samples, whereas in colon 4 where the levels of reduced ANXA2 were similar in normal and tumor samples we only observed a significant oxidation of total proteins in the core/hypoxic tumor, which is under higher oxidative stress due to lack of blood supply.