TP53 and nasopharyngeal carcinoma: We then proceeded to check the expression levels of endogenous and exogenous p53 protein levels in EBV negative HONE1 and EBV positive HONE-Akata cells, either treated or untreated with Actinomycin D. We found that EBV-positive HONE-Akata NPC cells had lower levels of p53 protein in comparison to EBV-negative HONE1 NPC cells.