NFKB1 and diabetes mellitus: Therefore, the evaluation of the molecular mechanisms of natural products-induced anti-inflammatory effects may provide novel means to regulate cellular function and to control NF-κB-dependent gene expression for therapeutic purposes, and such a new approach towards the role of nitric oxide in cellular signaling may lead to improved treatments for major diseases, including cardiovascular disease, diabetes, cancer, ageing and neurodegenerative disorders [25].