In fact, the expression and prognostic value of NSE has been investigated in several other tumors, including non small cell lung cancer [30], breast cancer [31] and prostate cancer [32]; however, the expression of NSE in lung cancer and breast cancer is associated with better survival, while NSE staining was associated with shorter survival [32] or was of no practical value as an independent prognostic indicator in patients with prostate cancer [33]. The gene discussed is ENO2; the disease is breast carcinoma.