SAV1 and nonpapillary renal cell carcinoma: To confirm this trend in ccRCC cases, quantitative RT-PCR (qRT-PCR) analysis of ccRCC samples was performed, and this revealed that the levels of SAV1 mRNA in cases showing 14q loss (n = 10) were significantly lower than those without 14q loss (n = 12) (p < 0.005), although they were similar between cases without 14q loss and normal kidney (Figure 1b).