One previous report, also starting with a nonbiased micro-array strategy, found an impressive induction of mRNA for IL-12Rβ2 in peripheral blood mononuclear cells of MS patients treated with IFN-β, and suggested a possible role of the IL-12 receptor (IL-12R) in the MOA of IFN-β [8]. Here, IFNB1 is linked to myeloid sarcoma.