ACKR3 and neoplasm: Notably, when compared with high expression of these single markers, concomitant and high expression of any two of the three markers was statistically significantly associated with tumor size in patients with colorectal carcinoma (p<0.001 for TLR4/MD-2, p = 0.001 for TLR4/CXCR7 and p<0.001 for MD-2/CXCR7; Table 2).