At the same time, the incidence of lymph node metastasis tended to be higher in patients with colorectal carcinoma with high rather than low expression of TLR4, MD-2, or CXCR7 (p = 0.001, p = 0.012, p<0.001, resp.; Table 1). This evidence concerns the gene ACKR3 and colorectal carcinoma.