Subsequently, we used a novel CXCR7-specific antagonist CCX771 and an endogenous CXCR7 ligand (CXCL12) to investigate the role of CXCR7 in regulating CXCL12-mediated colorectal carcinoma cell proliferation, apoptosis and migration. This evidence concerns the gene ACKR3 and colorectal carcinoma.