As shown in Table 2, there were statistically significant differences in high expression of these single molecules, and high expression of two of the three molecules TLR4/MD-2, TLR4/CXCR7, TLR4/CXCR7 with regard to lymph node metastasis in patients with colorectal carcinoma (p<0.001, p<0.001, p = 0.001, resp). This evidence concerns the gene ACKR3 and colorectal carcinoma.