TLR4 and colorectal carcinoma: Moreover, there are statistically significant differences in high expression of single TLR4, MD-2, or CXCR7 molecules, and high expression of both of TLR4/CXCR7, or MD-2/CXCR7 molecules with regard to distant metastasis in patients with colorectal carcinoma (p = 0.009, p = 0.001, resp.; Table 2).