In our previous study, genome-wide analysis of methylation alterations using a methylation-sensitive representational difference analysis identified the Pleckstrin and Sec7 domain-containing (PSD) gene (13), which has similar roles to DLG5, such as coordination of cell shape and polarity PSD was more frequently methylated in both UC-associated colorectal cancer tissues (71.4%) and matched normal epithelia (57.1%) than in non-neoplastic UC epithelia (27.3%) and sporadic colorectal cancer tissue (18.8%). Here, PLEK is linked to colorectal cancer.