If HbA1c < 6.5%'Within target for type 2 diabetes'If HbA1c 6.5 to 7.0%'For type 2 diabetes, consider increasing oral therapy'If HbA1c 7.0 to 8.0%'If type 2 diabetes: on max oral therapy, e.g., Metformin 1G BD + gliclazide 160 mg BD?'If HbA1c > 8.0%'If type 2 diabetes, consider insulin if on max oral Rx, e.g., Metformin 1G BD + gliclazide 160 mg BD'. The gene discussed is INS; the disease is type 2 diabetes mellitus.