Sorafenib, a multitargeted tyrosine kinase inhibitor of BRAF, CRAF, platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR) 2, p38, and CKIT which was the first RAF-inhibitor actively studied in patients with melanoma as it was available for phase II testing in the same year in which BRAF mutations were first reported. Here, BRAF is linked to melanoma.