During the acute SIVmac239 infection, the percentage of CD80+ CD1c+ mDCs increased from 1.36±0.24% to the peak at day 10 (15.25±8.61%) and sustained a high percentage till day 19 (3.93±0.48%), and showed a significant increase at day 19 (P = 0.011). Here, CD1C is linked to infection.