The promoter hypermethylation of several genes including p16INK4α, cadherin 13 (CDH13), Ras association (RalGDS/AF-6) domain family member 1 (RASSF1A) and adenomatous polyposis coli (APC) in NSCLC specimens is associated with early recurrence after surgery [17]. Here, CDKN2A is linked to non-small cell lung carcinoma.