In addition to the association with complement pathway genes, AMD has been convincingly shown to be associated with two adjacent genes on 10q26 (age-related maculopathy susceptibility 2 [ARMS2] and high-temperature requirement factor H [HTRA1]) [14]–[16], which together account for nearly half of the heritability of AMD [7]. The gene discussed is HTRA1; the disease is age-related macular degeneration.