NOD mice, used as a model to study SjS features [25], presented reduced salivary functioning compared to BALB/c controls (p = 0.05; Fig. 2A), and their salivary glands showed higher levels of cleaved caspase-3 (p = 0.05), suggesting accelerated apoptosis (Fig. 2B). The gene discussed is CASP3; the disease is Schwartz-Jampel syndrome.