For example, an SNP in the matrix metalloproteinase-12 (MMP-12) promoter influences the binding of transcription factor AP-1 and is associated with coronary artery disease [39], and a SNP in the promoter region of interleukin 4 (IL4) affects the binding of transcription factor NFAT, resulting in a 3-fold difference in IL4 expression [40]. This evidence concerns the gene MMP12 and coronary artery disorder.