ZEB1 and cancer: Many investigators have established that in tumorigenesis, one of the fundamental roles of the miR-200 family is to maintain an epithelial phenotype (i.e., preventing epithelial-to-mesenchymal transition) via its gene targets Zeb1 and Zeb2, the transcriptional suppressors of E-cadherin [25], [26], thus preventing a cancer cell from initiating the process of metastasis.