Our results demonstrated that the expression levels of CTLA-4 and GITR were higher in patients with B-cell NHL than those in HVs, suggesting that CTLA-4 and GITR may be involved in modulating suppressive capacity of Treg in human, which might be one of the reasons of higher suppressive ability of Treg from involved lymphatic tissues. This evidence concerns the gene CTLA4 and B-cell non-Hodgkin lymphoma.