In the case of West Nile virus (WNV) infection, only interferon lambda-induced activation of Jak-STAT signaling pathway and induction of ISG expression were completely inhibited in WNV replicon-containing cell lines, but interferon alfa signal transduction was either unaffected or only partially inhibited in Huh7.5 or Hela cells by the virus [27]. Here, SOAT1 is linked to infection.