Decreased levels of methylation are seen in genes such as calcyphosin which exhibits oncogenic properties in endometrial cancer [59], lactate dehydrogenase which when inhibited impairs cell proliferation via the Warburg effect of aerobic glycolysis in cancer cells [60] and DUB3, the CDC25A stabilizing protein ubiquitin hyrdolase [61] which has been shown to rescue CDC25A from proteasomal degradation and promote an oncogenic induction response [62]. The gene discussed is USP17L2; the disease is cancer.